diff --git a/patches/d3d11-dynamic-cpu-access/definition b/patches/d3d11-dynamic-cpu-access/definition
index 2bb2ef6a..dd4130cd 100644
--- a/patches/d3d11-dynamic-cpu-access/definition
+++ b/patches/d3d11-dynamic-cpu-access/definition
@@ -1 +1,3 @@
+# Causes regression on latest nVidia Driver
 Fixes: [45066] - Enable CPU access for dynamic buffers.
+Disabled: true
diff --git a/patches/patchinstall.sh b/patches/patchinstall.sh
index 12e8703b..95604123 100755
--- a/patches/patchinstall.sh
+++ b/patches/patchinstall.sh
@@ -110,7 +110,6 @@ patch_enable_all ()
 	enable_d2d1_ID2D1Factory1="$1"
 	enable_d3d11_Deferred_Context="$1"
 	enable_d3d11_Depth_Bias="$1"
-	enable_d3d11_dynamic_cpu_access="$1"
 	enable_d3d8_ValidateShader="$1"
 	enable_d3d9_DesktopWindow="$1"
 	enable_d3d9_Tests="$1"
@@ -512,9 +511,6 @@ patch_enable ()
 		d3d11-Depth_Bias)
 			enable_d3d11_Depth_Bias="$2"
 			;;
-		d3d11-dynamic-cpu-access)
-			enable_d3d11_dynamic_cpu_access="$2"
-			;;
 		d3d8-ValidateShader)
 			enable_d3d8_ValidateShader="$2"
 			;;
@@ -3150,21 +3146,6 @@ if test "$enable_d3d11_Depth_Bias" -eq 1; then
 	) >> "$patchlist"
 fi
 
-# Patchset d3d11-dynamic-cpu-access
-# |
-# | This patchset fixes the following Wine bugs:
-# |   *	[#45066] - Enable CPU access for dynamic buffers.
-# |
-# | Modified files:
-# |   *	dlls/d3d11/buffer.c
-# |
-if test "$enable_d3d11_dynamic_cpu_access" -eq 1; then
-	patch_apply d3d11-dynamic-cpu-access/0001-d3d11-D3D11_USAGE_DYNAMIC-needs-to-have-CPU-access.patch
-	(
-		printf '%s\n' '+    { "Alistair Leslie-Hughes", "d3d11: D3D11_USAGE_DYNAMIC needs to have CPU access.", 1 },';
-	) >> "$patchlist"
-fi
-
 # Patchset d3d8-ValidateShader
 # |
 # | This patchset fixes the following Wine bugs: