diff --git a/patches/kernelbase-CreateFile2/0001-kernelbase-Also-pass-CreateFile2-flags-to-CreateFile.patch b/patches/kernelbase-CreateFile2/0001-kernelbase-Also-pass-CreateFile2-flags-to-CreateFile.patch
new file mode 100644
index 00000000..ca7dbbaf
--- /dev/null
+++ b/patches/kernelbase-CreateFile2/0001-kernelbase-Also-pass-CreateFile2-flags-to-CreateFile.patch
@@ -0,0 +1,29 @@
+From 94c8ff1915712fb6fe00804ba618dac7633db432 Mon Sep 17 00:00:00 2001
+From: =?UTF-8?q?R=C3=A9mi=20Bernon?= <rbernon@codeweavers.com>
+Date: Tue, 8 Sep 2020 17:17:48 +0200
+Subject: [PATCH] kernelbase: Also pass CreateFile2 flags to CreateFileW.
+
+Instead of just attributes.
+
+Otherwise we may miss important flags like FILE_FLAG_OVERLAPPED and open
+the file for synchronous I/O, causing a deadlock in Flight Simulator.
+---
+ dlls/kernelbase/file.c | 2 +-
+ 1 file changed, 1 insertion(+), 1 deletion(-)
+
+diff --git a/dlls/kernelbase/file.c b/dlls/kernelbase/file.c
+index e022a29478e..4f30caaac7c 100644
+--- a/dlls/kernelbase/file.c
++++ b/dlls/kernelbase/file.c
+@@ -718,7 +718,7 @@ HANDLE WINAPI DECLSPEC_HOTPATCH CreateFile2( LPCWSTR name, DWORD access, DWORD s
+                                              CREATEFILE2_EXTENDED_PARAMETERS *params )
+ {
+     LPSECURITY_ATTRIBUTES sa = params ? params->lpSecurityAttributes : NULL;
+-    DWORD attributes = params ? params->dwFileAttributes : 0;
++    DWORD attributes = params ? (params->dwFileAttributes | params->dwFileFlags) : 0;
+     HANDLE template = params ? params->hTemplateFile : NULL;
+ 
+     FIXME( "(%s %x %x %x %p), partial stub\n", debugstr_w(name), access, sharing, creation, params );
+-- 
+2.28.0
+
diff --git a/patches/kernelbase-CreateFile2/definition b/patches/kernelbase-CreateFile2/definition
new file mode 100644
index 00000000..42764e82
--- /dev/null
+++ b/patches/kernelbase-CreateFile2/definition
@@ -0,0 +1 @@
+Fixes: [49740] kernelbase: Also pass CreateFile2 flags to CreateFileW.
diff --git a/patches/patchinstall.sh b/patches/patchinstall.sh
index aecca5fe..022bd7fe 100755
--- a/patches/patchinstall.sh
+++ b/patches/patchinstall.sh
@@ -145,6 +145,7 @@ patch_enable_all ()
 	enable_kernel32_Job_Tests="$1"
 	enable_kernel32_Processor_Group="$1"
 	enable_kernel32_SetProcessDEPPolicy="$1"
+	enable_kernelbase_CreateFile2="$1"
 	enable_krnl386_exe16_GDT_LDT_Emulation="$1"
 	enable_krnl386_exe16_Invalid_Console_Handles="$1"
 	enable_loader_KeyboardLayouts="$1"
@@ -530,6 +531,9 @@ patch_enable ()
 		kernel32-SetProcessDEPPolicy)
 			enable_kernel32_SetProcessDEPPolicy="$2"
 			;;
+		kernelbase-CreateFile2)
+			enable_kernelbase_CreateFile2="$2"
+			;;
 		krnl386.exe16-GDT_LDT_Emulation)
 			enable_krnl386_exe16_GDT_LDT_Emulation="$2"
 			;;
@@ -1893,7 +1897,8 @@ fi
 # |   *	[#49740] combase: Implement CoCreateInstanceFromApp semi-stub.
 # |
 # | Modified files:
-# |   *	dlls/combase/combase.c, dlls/combase/combase.spec, dlls/ole32/ole32.spec
+# |   *	dlls/api-ms-win-core-com-l1-1-0/api-ms-win-core-com-l1-1-0.spec, dlls/api-ms-win-core-com-l1-1-1/api-ms-win-core-
+# | 	com-l1-1-1.spec, dlls/combase/combase.c, dlls/combase/combase.spec, dlls/ole32/ole32.spec
 # |
 if test "$enable_combase_CoCreateInstanceFromApp" -eq 1; then
 	patch_apply combase-CoCreateInstanceFromApp/0001-combase-Implement-CoCreateInstanceFromApp-semi-stub.patch
@@ -2710,6 +2715,18 @@ if test "$enable_kernel32_SetProcessDEPPolicy" -eq 1; then
 	patch_apply kernel32-SetProcessDEPPolicy/0003-kernel32-Make-system-DEP-policy-affect-GetProcessDEP.patch
 fi
 
+# Patchset kernelbase-CreateFile2
+# |
+# | This patchset fixes the following Wine bugs:
+# |   *	[#49740] kernelbase: Also pass CreateFile2 flags to CreateFileW.
+# |
+# | Modified files:
+# |   *	dlls/kernelbase/file.c
+# |
+if test "$enable_kernelbase_CreateFile2" -eq 1; then
+	patch_apply kernelbase-CreateFile2/0001-kernelbase-Also-pass-CreateFile2-flags-to-CreateFile.patch
+fi
+
 # Patchset krnl386.exe16-GDT_LDT_Emulation
 # |
 # | This patchset fixes the following Wine bugs: