diff --git a/patches/ntdll-set_context_reg/0001-ntdll-Do-not-cast-unaligned-pointer-to-M128A-in-set_.patch b/patches/ntdll-set_context_reg/0001-ntdll-Do-not-cast-unaligned-pointer-to-M128A-in-set_.patch
new file mode 100644
index 00000000..76de22a3
--- /dev/null
+++ b/patches/ntdll-set_context_reg/0001-ntdll-Do-not-cast-unaligned-pointer-to-M128A-in-set_.patch
@@ -0,0 +1,71 @@
+From 265879650f33f8c39fb2ed7a1b08cb33f064fcb2 Mon Sep 17 00:00:00 2001
+From: Sebastian Lackner <sebastian@fds-team.de>
+Date: Sun, 4 Jun 2017 16:26:03 +0200
+Subject: ntdll: Do not cast unaligned pointer to M128A in set_context_reg.
+
+---
+ dlls/ntdll/signal_x86_64.c | 48 +++++++++++++++++++++++-----------------------
+ 1 file changed, 24 insertions(+), 24 deletions(-)
+
+diff --git a/dlls/ntdll/signal_x86_64.c b/dlls/ntdll/signal_x86_64.c
+index f3f14c998d8..6edf4b9a90d 100644
+--- a/dlls/ntdll/signal_x86_64.c
++++ b/dlls/ntdll/signal_x86_64.c
+@@ -1154,30 +1154,30 @@ static void set_context_reg( CONTEXT *context, ULONG_PTR dw_reg, void *val )
+     case 14: context->R14 = *(ULONG64 *)val; break;
+     case 15: context->R15 = *(ULONG64 *)val; break;
+     case 16: context->Rip = *(ULONG64 *)val; break;
+-    case 17: context->u.s.Xmm0  = *(M128A *)val; break;
+-    case 18: context->u.s.Xmm1  = *(M128A *)val; break;
+-    case 19: context->u.s.Xmm2  = *(M128A *)val; break;
+-    case 20: context->u.s.Xmm3  = *(M128A *)val; break;
+-    case 21: context->u.s.Xmm4  = *(M128A *)val; break;
+-    case 22: context->u.s.Xmm5  = *(M128A *)val; break;
+-    case 23: context->u.s.Xmm6  = *(M128A *)val; break;
+-    case 24: context->u.s.Xmm7  = *(M128A *)val; break;
+-    case 25: context->u.s.Xmm8  = *(M128A *)val; break;
+-    case 26: context->u.s.Xmm9  = *(M128A *)val; break;
+-    case 27: context->u.s.Xmm10 = *(M128A *)val; break;
+-    case 28: context->u.s.Xmm11 = *(M128A *)val; break;
+-    case 29: context->u.s.Xmm12 = *(M128A *)val; break;
+-    case 30: context->u.s.Xmm13 = *(M128A *)val; break;
+-    case 31: context->u.s.Xmm14 = *(M128A *)val; break;
+-    case 32: context->u.s.Xmm15 = *(M128A *)val; break;
+-    case 33: context->u.s.Legacy[0] = *(M128A *)val; break;
+-    case 34: context->u.s.Legacy[1] = *(M128A *)val; break;
+-    case 35: context->u.s.Legacy[2] = *(M128A *)val; break;
+-    case 36: context->u.s.Legacy[3] = *(M128A *)val; break;
+-    case 37: context->u.s.Legacy[4] = *(M128A *)val; break;
+-    case 38: context->u.s.Legacy[5] = *(M128A *)val; break;
+-    case 39: context->u.s.Legacy[6] = *(M128A *)val; break;
+-    case 40: context->u.s.Legacy[7] = *(M128A *)val; break;
++    case 17: memcpy( &context->u.s.Xmm0, val, sizeof(M128A) ); break;
++    case 18: memcpy( &context->u.s.Xmm1, val, sizeof(M128A) ); break;
++    case 19: memcpy( &context->u.s.Xmm2, val, sizeof(M128A) ); break;
++    case 20: memcpy( &context->u.s.Xmm3, val, sizeof(M128A) ); break;
++    case 21: memcpy( &context->u.s.Xmm4, val, sizeof(M128A) ); break;
++    case 22: memcpy( &context->u.s.Xmm5, val, sizeof(M128A) ); break;
++    case 23: memcpy( &context->u.s.Xmm6, val, sizeof(M128A) ); break;
++    case 24: memcpy( &context->u.s.Xmm7, val, sizeof(M128A) ); break;
++    case 25: memcpy( &context->u.s.Xmm8, val, sizeof(M128A) ); break;
++    case 26: memcpy( &context->u.s.Xmm9, val, sizeof(M128A) ); break;
++    case 27: memcpy( &context->u.s.Xmm10, val, sizeof(M128A) ); break;
++    case 28: memcpy( &context->u.s.Xmm11, val, sizeof(M128A) ); break;
++    case 29: memcpy( &context->u.s.Xmm12, val, sizeof(M128A) ); break;
++    case 30: memcpy( &context->u.s.Xmm13, val, sizeof(M128A) ); break;
++    case 31: memcpy( &context->u.s.Xmm14, val, sizeof(M128A) ); break;
++    case 32: memcpy( &context->u.s.Xmm15, val, sizeof(M128A) ); break;
++    case 33: memcpy( &context->u.s.Legacy[0], val, sizeof(M128A) ); break;
++    case 34: memcpy( &context->u.s.Legacy[1], val, sizeof(M128A) ); break;
++    case 35: memcpy( &context->u.s.Legacy[2], val, sizeof(M128A) ); break;
++    case 36: memcpy( &context->u.s.Legacy[3], val, sizeof(M128A) ); break;
++    case 37: memcpy( &context->u.s.Legacy[4], val, sizeof(M128A) ); break;
++    case 38: memcpy( &context->u.s.Legacy[5], val, sizeof(M128A) ); break;
++    case 39: memcpy( &context->u.s.Legacy[6], val, sizeof(M128A) ); break;
++    case 40: memcpy( &context->u.s.Legacy[7], val, sizeof(M128A) ); break;
+     }
+ }
+ 
+-- 
+2.13.0
+
diff --git a/patches/ntdll-set_context_reg/definition b/patches/ntdll-set_context_reg/definition
new file mode 100644
index 00000000..e4ac3eb5
--- /dev/null
+++ b/patches/ntdll-set_context_reg/definition
@@ -0,0 +1 @@
+Fixes: [43127] Avoid conversion from unaligned pointer to M128A
diff --git a/patches/patchinstall.sh b/patches/patchinstall.sh
index 96fa19e0..cd235f37 100755
--- a/patches/patchinstall.sh
+++ b/patches/patchinstall.sh
@@ -281,6 +281,7 @@ patch_enable_all ()
 	enable_ntdll_Zero_mod_name="$1"
 	enable_ntdll__aulldvrm="$1"
 	enable_ntdll_call_thread_func_wrapper="$1"
+	enable_ntdll_set_context_reg="$1"
 	enable_ntoskrnl_DriverTest="$1"
 	enable_ntoskrnl_Stubs="$1"
 	enable_nvapi_Stub_DLL="$1"
@@ -1081,6 +1082,9 @@ patch_enable ()
 		ntdll-call_thread_func_wrapper)
 			enable_ntdll_call_thread_func_wrapper="$2"
 			;;
+		ntdll-set_context_reg)
+			enable_ntdll_set_context_reg="$2"
+			;;
 		ntoskrnl-DriverTest)
 			enable_ntoskrnl_DriverTest="$2"
 			;;
@@ -6291,6 +6295,21 @@ if test "$enable_ntdll_call_thread_func_wrapper" -eq 1; then
 	) >> "$patchlist"
 fi
 
+# Patchset ntdll-set_context_reg
+# |
+# | This patchset fixes the following Wine bugs:
+# |   *	[#43127] Avoid conversion from unaligned pointer to M128A
+# |
+# | Modified files:
+# |   *	dlls/ntdll/signal_x86_64.c
+# |
+if test "$enable_ntdll_set_context_reg" -eq 1; then
+	patch_apply ntdll-set_context_reg/0001-ntdll-Do-not-cast-unaligned-pointer-to-M128A-in-set_.patch
+	(
+		printf '%s\n' '+    { "Sebastian Lackner", "ntdll: Do not cast unaligned pointer to M128A in set_context_reg.", 1 },';
+	) >> "$patchlist"
+fi
+
 # Patchset ntoskrnl-DriverTest
 # |
 # | Modified files: