diff --git a/patches/ntdll-Syscall_Emulation/0001-ntdll-Support-x86_64-syscall-emulation.patch b/patches/ntdll-Syscall_Emulation/0001-ntdll-Support-x86_64-syscall-emulation.patch
index 96d3690b..9db342b2 100644
--- a/patches/ntdll-Syscall_Emulation/0001-ntdll-Support-x86_64-syscall-emulation.patch
+++ b/patches/ntdll-Syscall_Emulation/0001-ntdll-Support-x86_64-syscall-emulation.patch
@@ -1,19 +1,19 @@
-From 39a48f5e0d94090a9461705feeb30759b366fc4d Mon Sep 17 00:00:00 2001
+From 30a823033f450475796b7d24a757ef3b00be46fa Mon Sep 17 00:00:00 2001
 From: Paul Gofman <pgofman@codeweavers.com>
 Date: Tue, 14 Jul 2020 15:00:34 +0300
 Subject: [PATCH] ntdll: Support x86_64 syscall emulation.
 
 ---
  configure.ac                    |   1 +
- dlls/ntdll/unix/signal_x86_64.c | 117 ++++++++++++++++++++++++++++++++
+ dlls/ntdll/unix/signal_x86_64.c | 122 ++++++++++++++++++++++++++++++++
  tools/winebuild/import.c        |   3 +-
- 3 files changed, 119 insertions(+), 2 deletions(-)
+ 3 files changed, 124 insertions(+), 2 deletions(-)
 
 diff --git a/configure.ac b/configure.ac
-index ffd92c988ac..58d95ff6df3 100644
+index 4b03c869d5e0..477266b8ba80 100644
 --- a/configure.ac
 +++ b/configure.ac
-@@ -481,6 +481,7 @@ AC_CHECK_HEADERS(\
+@@ -487,6 +487,7 @@ AC_CHECK_HEADERS(\
  	linux/joystick.h \
  	linux/major.h \
  	linux/param.h \
@@ -22,7 +22,7 @@ index ffd92c988ac..58d95ff6df3 100644
  	linux/types.h \
  	linux/ucdrom.h \
 diff --git a/dlls/ntdll/unix/signal_x86_64.c b/dlls/ntdll/unix/signal_x86_64.c
-index da548eb1a49..82e07eb25cf 100644
+index da548eb1a492..2fb3eab73594 100644
 --- a/dlls/ntdll/unix/signal_x86_64.c
 +++ b/dlls/ntdll/unix/signal_x86_64.c
 @@ -28,6 +28,7 @@
@@ -47,7 +47,7 @@ index da548eb1a49..82e07eb25cf 100644
  #define NONAMELESSUNION
  #define NONAMELESSSTRUCT
  #include "ntstatus.h"
-@@ -2426,6 +2434,114 @@ static inline DWORD is_privileged_instr( CONTEXT *context )
+@@ -2426,6 +2434,118 @@ static inline DWORD is_privileged_instr( CONTEXT *context )
      return 0;
  }
  
@@ -123,12 +123,16 @@ index da548eb1a49..82e07eb25cf 100644
 +       BPF_STMT(BPF_RET | BPF_K, SECCOMP_RET_TRAP),
 +       BPF_STMT(BPF_RET | BPF_K, SECCOMP_RET_ALLOW),
 +    };
++    struct syscall_frame *frame = amd64_thread_data()->syscall_frame;
 +    struct sock_fprog prog;
 +    NTSTATUS status;
 +
 +    sig_act->sa_sigaction = sigsys_handler;
 +    sigaction(SIGSYS, sig_act, NULL);
 +
++    frame->syscall_flags = syscall_flags;
++    frame->syscall_table = KeServiceDescriptorTable;
++
 +    if ((status = syscall(0xffff)) == STATUS_INVALID_PARAMETER)
 +    {
 +        TRACE("Seccomp filters already installed.\n");
@@ -162,7 +166,7 @@ index da548eb1a49..82e07eb25cf 100644
  
  /***********************************************************************
   *           handle_interrupt
-@@ -3004,6 +3120,7 @@ void signal_init_process(void)
+@@ -3004,6 +3124,7 @@ void signal_init_process(void)
      if (sigaction( SIGSEGV, &sig_act, NULL ) == -1) goto error;
      if (sigaction( SIGILL, &sig_act, NULL ) == -1) goto error;
      if (sigaction( SIGBUS, &sig_act, NULL ) == -1) goto error;
@@ -170,8 +174,16 @@ index da548eb1a49..82e07eb25cf 100644
      return;
  
   error:
+@@ -3222,6 +3343,7 @@ __ASM_GLOBAL_FUNC( __wine_syscall_dispatcher,
+                    "leaq 0x28(%rsp),%rsi\n\t"      /* first argument */
+                    "movq %rcx,%rsp\n\t"
+                    "movq 0x00(%rcx),%rax\n\t"
++                   "subq $0xf000,%rax\n\t"
+                    "movq 0x18(%rcx),%rdx\n\t"
+                    "movl %eax,%ebx\n\t"
+                    "shrl $8,%ebx\n\t"
 diff --git a/tools/winebuild/import.c b/tools/winebuild/import.c
-index 6a158578143..dc04a321474 100644
+index 6a1585781431..dc04a3214749 100644
 --- a/tools/winebuild/import.c
 +++ b/tools/winebuild/import.c
 @@ -1419,7 +1419,6 @@ static int cmp_link_name( const void *e1, const void *e2 )
@@ -192,5 +204,5 @@ index 6a158578143..dc04a321474 100644
              output( "\t.byte 0x75,0x03\n" );      /* jne 1f */
              output( "\t.byte 0x0f,0x05\n" );      /* syscall */
 -- 
-2.32.0
+2.31.1
 
diff --git a/patches/ntdll-Syscall_Emulation/definition b/patches/ntdll-Syscall_Emulation/definition
index 02593d00..89b59eb0 100644
--- a/patches/ntdll-Syscall_Emulation/definition
+++ b/patches/ntdll-Syscall_Emulation/definition
@@ -1,2 +1 @@
 Fixes: [48291] Detroit: Become Human crashes on launch
-Disabled: True
diff --git a/patches/patchinstall.sh b/patches/patchinstall.sh
index 3bcf5037..e73af127 100755
--- a/patches/patchinstall.sh
+++ b/patches/patchinstall.sh
@@ -166,6 +166,7 @@ patch_enable_all ()
 	enable_ntdll_RtlFirstFreeAce="$1"
 	enable_ntdll_RtlQueryPackageIdentity="$1"
 	enable_ntdll_Serial_Port_Detection="$1"
+	enable_ntdll_Syscall_Emulation="$1"
 	enable_ntdll_WRITECOPY="$1"
 	enable_ntdll_Zero_mod_name="$1"
 	enable_ntdll_ext4_case_folder="$1"
@@ -537,6 +538,9 @@ patch_enable ()
 		ntdll-Serial_Port_Detection)
 			enable_ntdll_Serial_Port_Detection="$2"
 			;;
+		ntdll-Syscall_Emulation)
+			enable_ntdll_Syscall_Emulation="$2"
+			;;
 		ntdll-WRITECOPY)
 			enable_ntdll_WRITECOPY="$2"
 			;;
@@ -2759,6 +2763,18 @@ if test "$enable_ntdll_Serial_Port_Detection" -eq 1; then
 	patch_apply ntdll-Serial_Port_Detection/0001-ntdll-Do-a-device-check-before-returning-a-default-s.patch
 fi
 
+# Patchset ntdll-Syscall_Emulation
+# |
+# | This patchset fixes the following Wine bugs:
+# |   *	[#48291] Detroit: Become Human crashes on launch
+# |
+# | Modified files:
+# |   *	configure.ac, dlls/ntdll/unix/signal_x86_64.c, tools/winebuild/import.c
+# |
+if test "$enable_ntdll_Syscall_Emulation" -eq 1; then
+	patch_apply ntdll-Syscall_Emulation/0001-ntdll-Support-x86_64-syscall-emulation.patch
+fi
+
 # Patchset ntdll-Zero_mod_name
 # |
 # | Modified files: