diff --git a/build/autoconf/toolchain.m4 b/build/autoconf/toolchain.m4
index 4a2dfcf669e..e6f24937dd9 100644
--- a/build/autoconf/toolchain.m4
+++ b/build/autoconf/toolchain.m4
@@ -161,6 +161,7 @@ MOZ_PATH_PROGS(AS, "${target_alias}-as" "${target}-as", :)
 AC_CHECK_PROGS(LD, "${target_alias}-ld" "${target}-ld", :)
 AC_CHECK_PROGS(STRIP, "${target_alias}-strip" "${target}-strip", :)
 AC_CHECK_PROGS(WINDRES, "${target_alias}-windres" "${target}-windres", :)
+AC_CHECK_PROGS(OTOOL, "${target_alias}-otool" "${target}-otool", :)
 AC_DEFINE(CROSS_COMPILE)
 CROSS_COMPILE=1
 
diff --git a/build/macosx/universal/mozconfig.common b/build/macosx/universal/mozconfig.common
index c351b304cc6..518274b51bc 100644
--- a/build/macosx/universal/mozconfig.common
+++ b/build/macosx/universal/mozconfig.common
@@ -42,12 +42,13 @@ if test "$MOZ_BUILD_APP" = "i386" -o "$MOZ_BUILD_APP" = "x86_64"; then
   AS=$CC
   LD=ld
   STRIP="strip"
+  OTOOL="otool"
 
   # Each per-CPU build should be entirely oblivious to the fact that a
   # universal binary will be produced.  The exception is packager.mk, which
   # needs to know to look for universal bits when building the .dmg.
   UNIVERSAL_BINARY=1
 
-  export CC CXX HOST_CC HOST_CXX RANLIB AR AS LD STRIP
+  export CC CXX HOST_CC HOST_CXX RANLIB AR AS LD STRIP OTOOL
 fi
 fi
diff --git a/build/unix/rewrite_asan_dylib.py b/build/unix/rewrite_asan_dylib.py
index 869c46e2957..6e30374b724 100644
--- a/build/unix/rewrite_asan_dylib.py
+++ b/build/unix/rewrite_asan_dylib.py
@@ -6,6 +6,7 @@ import sys
 import os
 import subprocess
 import shutil
+from buildconfig import substs
 
 '''
 Scans the given directories for binaries referencing the AddressSanitizer
@@ -28,7 +29,7 @@ def scan_directory(path):
                 continue
 
             try:
-                otoolOut = subprocess.check_output(['otool', '-L', filename])
+                otoolOut = subprocess.check_output([substs['OTOOL'], '-L', filename])
             except:
                 # Errors are expected on non-mach executables, ignore them and continue
                 continue
diff --git a/configure.in b/configure.in
index 1aae34cf00f..4f5126533b4 100644
--- a/configure.in
+++ b/configure.in
@@ -370,6 +370,7 @@ else
     AC_CHECK_PROGS(LD, ld, :)
     AC_CHECK_PROGS(STRIP, strip, :)
     AC_CHECK_PROGS(WINDRES, windres, :)
+    AC_CHECK_PROGS(OTOOL, otool, :)
     if test -z "$HOST_CC"; then
         HOST_CC="$CC"
     fi
@@ -7173,12 +7174,12 @@ elif test -n "$MOZ_REPLACE_MALLOC"; then
                  dnl - classic info only (for OSX < 10.6)
                  dnl - dyld info only
                  dnl - both
-                 if otool -l conftest${DLL_SUFFIX} 2> /dev/null | grep "LC_DYLD_INFO_ONLY" > /dev/null; then
+                 if "$OTOOL" -l conftest${DLL_SUFFIX} 2> /dev/null | grep "LC_DYLD_INFO_ONLY" > /dev/null; then
                      _CLASSIC_INFO=
                  else
                      _CLASSIC_INFO=1
                  fi
-                 if otool -l conftest${DLL_SUFFIX} 2> /dev/null | grep "LC_DYLD_INFO" > /dev/null; then
+                 if "$OTOOL" -l conftest${DLL_SUFFIX} 2> /dev/null | grep "LC_DYLD_INFO" > /dev/null; then
                      _DYLD_INFO=1
                  else
                      _DYLD_INFO=
diff --git a/toolkit/library/dependentlibs.py b/toolkit/library/dependentlibs.py
index 43433a1b0d8..f4e249021b1 100644
--- a/toolkit/library/dependentlibs.py
+++ b/toolkit/library/dependentlibs.py
@@ -17,6 +17,7 @@ from mozpack.executables import (
     ELF,
     MACHO,
 )
+from buildconfig import substs
 
 TOOLCHAIN_PREFIX = ''
 
@@ -71,7 +72,7 @@ def dependentlibs_readelf(lib):
 
 def dependentlibs_otool(lib):
     '''Returns the list of dependencies declared in the given MACH-O dylib'''
-    proc = subprocess.Popen(['otool', '-l', lib], stdout = subprocess.PIPE)
+    proc = subprocess.Popen([substs['OTOOL'], '-l', lib], stdout = subprocess.PIPE)
     deps= []
     cmd = None
     for line in proc.stdout: