diff --git a/build/gecko_templates.mozbuild b/build/gecko_templates.mozbuild
index 905ce038e03..8cadb91f6bb 100644
--- a/build/gecko_templates.mozbuild
+++ b/build/gecko_templates.mozbuild
@@ -25,7 +25,7 @@ def GeckoBinary(linkage='dependent', msvcrt='dynamic', mozglue=None):
     'program' (mozglue linked to an executable program), or 'library' (mozglue
     linked to a shared library).
     '''
-    if msvcrt == 'dynamic' or CONFIG['OS_ARCH'] != 'WINNT':
+    if msvcrt == 'dynamic' or CONFIG['OS_ARCH'] != 'WINNT' or CONFIG['MOZ_ASAN']:
         xpcomglue = 'xpcomglue'
     elif msvcrt == 'static':
         USE_STATIC_LIBS = True
diff --git a/config/config.mk b/config/config.mk
index 9741f053510..b9bc3ae27d2 100644
--- a/config/config.mk
+++ b/config/config.mk
@@ -381,6 +381,12 @@ ifeq ($(OS_ARCH)_$(GNU_CC),WINNT_)
 #// DLL version of the RTL is used...
 #//
 #//------------------------------------------------------------------------
+ifdef MOZ_ASAN
+# ASAN-instrumented code tries to link against the dynamic CRT, which can't be
+# used in the same link as the static CRT.
+USE_STATIC_LIBS=
+endif # MOZ_ASAN
+
 ifdef USE_STATIC_LIBS
 RTL_FLAGS=-MT          # Statically linked multithreaded RTL
 ifdef MOZ_DEBUG
diff --git a/ipc/app/moz.build b/ipc/app/moz.build
index fb2157ba7da..9337ba4219f 100644
--- a/ipc/app/moz.build
+++ b/ipc/app/moz.build
@@ -17,7 +17,7 @@ else:
     kwargs = {
         'linkage': None,
     }
-    if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT':
+    if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT' and not CONFIG['MOZ_ASAN']:
         kwargs['msvcrt'] = 'static'
         if not CONFIG['GNU_CC']:
             USE_LIBS += [
@@ -55,9 +55,17 @@ if CONFIG['MOZ_SANDBOX'] and CONFIG['OS_ARCH'] == 'WINNT':
     ]
     USE_LIBS += [
         'rlz',
-        'sandbox_staticruntime_s',
     ]
 
+    if CONFIG['MOZ_ASAN']:
+        USE_LIBS += [
+            'sandbox_s',
+        ]
+    else:
+        USE_LIBS += [
+            'sandbox_staticruntime_s',
+        ]
+
     # clang-cl can't deal with this delay-load due to bug 1188045
     # (also filed as https://llvm.org/bugs/show_bug.cgi?id=24291)
     if not CONFIG['CLANG_CL']: