diff --git a/dom/base/test/mochitest.ini b/dom/base/test/mochitest.ini
index 20e2bc32801..10650242fc3 100644
--- a/dom/base/test/mochitest.ini
+++ b/dom/base/test/mochitest.ini
@@ -411,6 +411,7 @@ skip-if = e10s # Bug 1081453 - shutdown leaks with e10s and WebIDL dom::File
 [test_bug380418.html]
 [test_bug380418.html^headers^]
 [test_bug382113.html]
+skip-if == (os == 'mac' || os == 'win') && debug # bug 453969
 [test_bug382871.html]
 [test_bug384003.xhtml]
 [test_bug390219.html]