diff --git a/Casks/u/unipro-ugene.rb b/Casks/u/unipro-ugene.rb
index f3e90bec60..fdeef4c9c0 100644
--- a/Casks/u/unipro-ugene.rb
+++ b/Casks/u/unipro-ugene.rb
@@ -1,6 +1,6 @@
 cask "unipro-ugene" do
-  version "48.1"
-  sha256 "fe8ad0faee40d200ac8fc801a76006ad5a3786843fc78d1788a77652b4cee435"
+  version "49.0"
+  sha256 "3c4c7eba5353eaa12592ccd89d9036707358fbb350c1138bc3403dda8979a3c0"
 
   url "https://github.com/ugeneunipro/ugene/releases/download/#{version}/ugene-#{version}-mac-x86-64.dmg",
       verified: "github.com/ugeneunipro/ugene/"