diff --git a/.buildkite/pipeline.yaml b/.buildkite/pipeline.yaml
index 06fec84ad..406621f03 100644
--- a/.buildkite/pipeline.yaml
+++ b/.buildkite/pipeline.yaml
@@ -526,7 +526,7 @@ steps:
   - <<: *common
     <<: *docker
     label: ":node: NodeJS runtime tests"
-    command: make nodejs16.13.2-runtime-tests RUNTIME_ARGS=--directfs
+    command: make nodejs22.2.0-runtime-tests RUNTIME_ARGS=--directfs
     parallelism: 10
     agents:
       <<: *platform_specific_agents
@@ -571,7 +571,7 @@ steps:
   - <<: *common
     <<: *docker
     label: ":node: NodeJS runtime tests (goferfs)"
-    command: make nodejs16.13.2-runtime-tests RUNTIME_ARGS=--directfs=false
+    command: make nodejs22.2.0-runtime-tests RUNTIME_ARGS=--directfs=false
     parallelism: 10
     if: build.branch == "master"
     agents:
diff --git a/images/runtimes/nodejs16.13.2/Dockerfile.x86_64 b/images/runtimes/nodejs22.2.0/Dockerfile.x86_64
similarity index 66%
rename from images/runtimes/nodejs16.13.2/Dockerfile.x86_64
rename to images/runtimes/nodejs22.2.0/Dockerfile.x86_64
index 051edb359..31a66edb4 100644
--- a/images/runtimes/nodejs16.13.2/Dockerfile.x86_64
+++ b/images/runtimes/nodejs22.2.0/Dockerfile.x86_64
@@ -1,20 +1,20 @@
-FROM ubuntu:bionic
+FROM ubuntu:jammy
 RUN apt-get update && apt-get install -y \
   curl \
   dumb-init \
   g++ \
   make \
-  python \
-  python3.8
+  python3.10
 
 WORKDIR /root
-ARG VERSION=v16.13.2
-RUN curl -o node-${VERSION}.tar.gz https://nodejs.org/dist/${VERSION}/node-${VERSION}.tar.gz
-RUN tar -zxf node-${VERSION}.tar.gz
+ARG VERSION=v22.2.0
+RUN curl -o node-${VERSION}.tar.gz https://nodejs.org/dist/${VERSION}/node-${VERSION}.tar.gz \
+ && tar -zxf node-${VERSION}.tar.gz \
+ && rm -f node-${VERSION}.tar.gz
 
 WORKDIR /root/node-${VERSION}
 RUN ./configure
-RUN make test-build
+RUN make -j $(nproc) test-build
 
 # Including dumb-init emulates the Linux "init" process, preventing the failure
 # of tests involving worker processes.
diff --git a/test/runtimes/BUILD b/test/runtimes/BUILD
index 310bd4ea2..e62ff43a0 100644
--- a/test/runtimes/BUILD
+++ b/test/runtimes/BUILD
@@ -22,8 +22,8 @@ runtime_test(
 )
 
 runtime_test(
-    name = "nodejs16.13.2",
-    exclude_file = "exclude/nodejs16.13.2.csv",
+    name = "nodejs22.2.0",
+    exclude_file = "exclude/nodejs22.2.0.csv",
     lang = "nodejs",
     shard_count = most_shards,
 )
diff --git a/test/runtimes/README.md b/test/runtimes/README.md
index 24eaefe47..9b070f826 100644
--- a/test/runtimes/README.md
+++ b/test/runtimes/README.md
@@ -27,10 +27,10 @@ The following `make` targets will run an entire runtime test suite locally.
 Note: java runtime test take 1+ hours with 16 cores.
 
 Language | Version | Running the test suite
--------- | ------- | ----------------------------------
+-------- | ------- | ---------------------------------
 Go       | 1.22    | `make go1.22-runtime-tests`
 Java     | 21      | `make java21-runtime-tests`
-NodeJS   | 16.13.2 | `make nodejs16.13.2-runtime-tests`
+NodeJS   | 22.2.0  | `make nodejs22.2.0-runtime-tests`
 Php      | 8.3.7   | `make php8.3.7-runtime-tests`
 Python   | 3.12.3  | `make python3.12.3-runtime-tests`
 
diff --git a/test/runtimes/exclude/nodejs16.13.2.csv b/test/runtimes/exclude/nodejs16.13.2.csv
deleted file mode 100644
index bdab7eeca..000000000
--- a/test/runtimes/exclude/nodejs16.13.2.csv
+++ /dev/null
@@ -1,15 +0,0 @@
-test name,bug id,comment
-benchmark/test-benchmark-napi.js,,Broken test
-internet/test-dgram-multicast-ssm-multi-process.js,,
-internet/test-dgram-multicast-ssmv6-multi-process.js,,Broken test
-internet/test-dns.js,,Broken test
-internet/test-dns-any.js,,Broken test
-internet/test-dns-ipv4.js,,Flaky on Buildkite because it relies on external network
-internet/test-inspector-help-page.js,,Broken test
-parallel/test-dns-lookupService-promises.js,,Broken test
-parallel/test-http-writable-true-after-close.js,b/171301436,Flaky
-parallel/test-https-selfsigned-no-keycertsign-no-crash.js,,Broken test
-pseudo-tty/test-stdout-read.js,b/162801321,
-tick-processor/test-tick-processor-builtin.js,,Broken test
-v8-updates/test-linux-perf.js,,Broken test
-wasi/test-wasi.js,,
diff --git a/test/runtimes/exclude/nodejs22.2.0.csv b/test/runtimes/exclude/nodejs22.2.0.csv
new file mode 100644
index 000000000..98744944b
--- /dev/null
+++ b/test/runtimes/exclude/nodejs22.2.0.csv
@@ -0,0 +1,13 @@
+test name,bug id,comment
+benchmark/test-benchmark-napi.js,,Broken test
+internet/test-dgram-multicast-ssm-multi-process.js,b/344592701,
+internet/test-dgram-multicast-ssmv6-multi-process.js,,Broken test
+internet/test-dns-ipv4.js,,Broken test (Flaky because it relies on external network)
+internet/test-inspector-help-page.js,,Broken test
+internet/test-net-autoselectfamily-events-failure.js,,Broken test
+internet/test-snapshot-dns-resolve.js,,Broken test (Flaky because it relies on external network)
+pseudo-tty/test-stdout-read.js,b/162801321,
+parallel/test-child-process-set-blocking.js,,Broken test
+pummel/test-child-process-spawn-loop.js,,Broken test
+tick-processor/test-tick-processor-builtin.js,,Broken test
+v8-updates/test-linux-perf.js,,Broken test
diff --git a/test/runtimes/proctor/lib/nodejs.go b/test/runtimes/proctor/lib/nodejs.go
index 320597aa5..9f5171e51 100644
--- a/test/runtimes/proctor/lib/nodejs.go
+++ b/test/runtimes/proctor/lib/nodejs.go
@@ -42,5 +42,5 @@ func (nodejsRunner) ListTests() ([]string, error) {
 // TestCmds implements TestRunner.TestCmds.
 func (nodejsRunner) TestCmds(tests []string) []*exec.Cmd {
 	args := append([]string{filepath.Join("tools", "test.py"), "--timeout=180"}, tests...)
-	return []*exec.Cmd{exec.Command("/usr/bin/python", args...)}
+	return []*exec.Cmd{exec.Command("/usr/bin/python3.10", args...)}
 }