diff --git a/pkg/seccomp/BUILD b/pkg/seccomp/BUILD
index 480945236..0c721654e 100644
--- a/pkg/seccomp/BUILD
+++ b/pkg/seccomp/BUILD
@@ -11,6 +11,7 @@ go_library(
         "seccomp.go",
         "seccomp_amd64.go",
         "seccomp_arm64.go",
+        "seccomp_fuzz_helpers.go",
         "seccomp_optimizer.go",
         "seccomp_rules.go",
         "seccomp_unsafe.go",
diff --git a/pkg/seccomp/seccomp_fuzz_helpers.go b/pkg/seccomp/seccomp_fuzz_helpers.go
new file mode 100644
index 000000000..567d31a25
--- /dev/null
+++ b/pkg/seccomp/seccomp_fuzz_helpers.go
@@ -0,0 +1,194 @@
+// Copyright 2018 The gVisor Authors.
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+package seccomp
+
+// This file contains helpers to generate fuzz tests for seccomp rules.
+// It contains the `InterestingValues` implementations for all matchers,
+// and a helper function to generate test cases based on `RuleSet`s.
+
+import (
+	"sort"
+
+	"gvisor.dev/gvisor/pkg/abi/linux"
+)
+
+// UsefulTestCases returns a best-effort list of test cases that may be
+// useful in fuzzing this set of rules.
+func (sr SyscallRules) UsefulTestCases() []linux.SeccompData {
+	var testCases []linux.SeccompData
+	for sysno, r := range sr.rules {
+
+		// valueMatchers maps argument indexes to value matchers
+		// seen for that argument index.
+		// valueMatchersRepr tracks the `Repr()` of those
+		// `ValueMatcher`s in order to avoid inserting duplicates.
+		valueMatchers := make(map[int][]ValueMatcher)
+		valueMatchersRepr := make(map[int]map[string]struct{})
+
+		// Find all unique `ValueMatcher`s for each argument.
+		var processRule func(SyscallRule) SyscallRule
+		processRule = func(r SyscallRule) SyscallRule {
+			r.Recurse(processRule)
+			pa, isPerArg := r.(PerArg)
+			if !isPerArg {
+				return r
+			}
+			for argNum, arg := range pa {
+				if arg == nil {
+					arg = AnyValue{}
+				}
+				valueMatchersReprMap, ok := valueMatchersRepr[argNum]
+				if !ok {
+					valueMatchersReprMap = make(map[string]struct{})
+					valueMatchersRepr[argNum] = valueMatchersReprMap
+				}
+				repr := arg.Repr()
+				if _, seen := valueMatchersReprMap[repr]; seen {
+					continue
+				}
+				valueMatchersReprMap[repr] = struct{}{}
+				valueMatchers[argNum] = append(valueMatchers[argNum], arg)
+			}
+			return r
+		}
+		processRule(r)
+
+		// Now compute the combination of all interesting values for them.
+		sysnoCases := []linux.SeccompData{{
+			Nr:   int32(sysno),
+			Arch: LINUX_AUDIT_ARCH,
+		}}
+		for argNum, vms := range valueMatchers {
+			// Deduplicate interesting values across value matchers.
+			interestingValuesMap := make(map[uint64]struct{})
+			interestingValuesMap[0] = struct{}{} // The zero value is always interesting.
+			for _, vm := range vms {
+				for _, interestingValue := range vm.InterestingValues() {
+					interestingValuesMap[interestingValue] = struct{}{}
+				}
+			}
+
+			// Convert to sorted slice of integers.
+			interestingValues := make([]uint64, 0, len(interestingValuesMap))
+			for interestingValue := range interestingValuesMap {
+				interestingValues = append(interestingValues, interestingValue)
+			}
+			sort.Slice(interestingValues, func(i, j int) bool {
+				return interestingValues[i] < interestingValues[j]
+			})
+
+			// Generate test cases.
+			newSysnoCases := make([]linux.SeccompData, 0, len(sysnoCases)*len(interestingValues))
+			for _, sysnoCase := range sysnoCases {
+				for _, interestingValue := range interestingValues {
+					if argNum == RuleIP {
+						sysnoCase.InstructionPointer = interestingValue
+					} else {
+						sysnoCase.Args[argNum] = interestingValue
+					}
+					newSysnoCases = append(newSysnoCases, sysnoCase)
+				}
+			}
+			sysnoCases = newSysnoCases
+		}
+		testCases = append(testCases, sysnoCases...)
+	}
+	return testCases
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (halfAnyValue) InterestingValues() []uint32 {
+	return []uint32{0}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (heq halfEqualTo) InterestingValues() []uint32 {
+	return []uint32{uint32(heq), uint32(heq + 1)}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (hns halfNotSet) InterestingValues() []uint32 {
+	return []uint32{uint32(hns), uint32(hns + 1)}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (hmeq halfMaskedEqual) InterestingValues() []uint32 {
+	return []uint32{uint32(hmeq.mask), uint32(hmeq.mask + 1)}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (sm splitMatcher) InterestingValues() []uint64 {
+	interestingHigh := sm.highMatcher.InterestingValues()
+	interestingLow := sm.lowMatcher.InterestingValues()
+	interesting := make([]uint64, 0, len(interestingHigh)*len(interestingLow))
+	for _, high := range interestingHigh {
+		for _, low := range interestingLow {
+			interesting = append(interesting, (uint64(high)<<32)|uint64(low))
+		}
+	}
+	return interesting
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (av AnyValue) InterestingValues() []uint64 {
+	return []uint64{0}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (eq EqualTo) InterestingValues() []uint64 {
+	return eq.split().InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (ne NotEqual) InterestingValues() []uint64 {
+	return EqualTo(ne).InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (gt GreaterThan) InterestingValues() []uint64 {
+	return []uint64{
+		uint64(high32Bits(uintptr(gt))+1) << 32,
+		uint64(high32Bits(uintptr(gt))-1) << 32,
+		uint64(high32Bits(uintptr(gt))) << 32,
+		(uint64(high32Bits(uintptr(gt))) << 32) + uint64(low32Bits(uintptr(gt))),
+		(uint64(high32Bits(uintptr(gt))) << 32) + uint64(low32Bits(uintptr(gt))) + 1,
+		(uint64(high32Bits(uintptr(gt))) << 32) + uint64(low32Bits(uintptr(gt))) - 1,
+	}
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (ge GreaterThanOrEqual) InterestingValues() []uint64 {
+	return GreaterThan(ge).InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (lt LessThan) InterestingValues() []uint64 {
+	return GreaterThan(lt).InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (le LessThanOrEqual) InterestingValues() []uint64 {
+	return GreaterThan(le).InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (nnfd NonNegativeFD) InterestingValues() []uint64 {
+	return nnfd.split().InterestingValues()
+}
+
+// InterestingValues implements `halfValueMatcher.InterestingValues`.
+func (me maskedEqual) InterestingValues() []uint64 {
+	return me.split().InterestingValues()
+}
diff --git a/pkg/seccomp/seccomp_rules.go b/pkg/seccomp/seccomp_rules.go
index 2a51ccb68..c9c784ae2 100644
--- a/pkg/seccomp/seccomp_rules.go
+++ b/pkg/seccomp/seccomp_rules.go
@@ -63,6 +63,10 @@ type ValueMatcher interface {
 	// The rules should indicate this by either jumping to `labelSet.Matched()`
 	// or `labelSet.Mismatched()`. They may not fall through.
 	Render(program *syscallProgram, labelSet *labelSet, value matchedValue)
+
+	// InterestingValues returns a list of values that may be interesting to
+	// test this `ValueMatcher` against.
+	InterestingValues() []uint64
 }
 
 // halfValueMatcher verifies a 32-bit value.
@@ -78,6 +82,10 @@ type halfValueMatcher interface {
 	// The rules should indicate this by either jumping to `labelSet.Matched()`
 	// or `labelSet.Mismatched()`. They may not fall through.
 	HalfRender(program *syscallProgram, labelSet *labelSet)
+
+	// InterestingValues returns a list of values that may be interesting to
+	// test this `halfValueMatcher` against.
+	InterestingValues() []uint32
 }
 
 // halfAnyValue implements `halfValueMatcher` and matches any value.
diff --git a/test/secfuzz/secfuzz.go b/test/secfuzz/secfuzz.go
index 9d1f466cc..76e552644 100644
--- a/test/secfuzz/secfuzz.go
+++ b/test/secfuzz/secfuzz.go
@@ -142,7 +142,11 @@ func (df *DiffFuzzer) defaultSeedCorpus() {
 // DeriveCorpusFromRuleSets attempts to extract useful seed corpus rules
 // out of the given `RuleSet`s.
 func (df *DiffFuzzer) DeriveCorpusFromRuleSets(ruleSets []seccomp.RuleSet) {
-	// TODO(b/298726675): Not implemented yet.
+	for _, ruleSet := range ruleSets {
+		for _, tc := range ruleSet.Rules.UsefulTestCases() {
+			df.AddSeed(tc)
+		}
+	}
 }
 
 // NewDiffFuzzer creates a fuzzer that verifies that two seccomp-bpf programs