diff --git a/science/SoapySDR/Portfile b/science/SoapySDR/Portfile
index 014a5477c3f..6e9d6fd0e91 100644
--- a/science/SoapySDR/Portfile
+++ b/science/SoapySDR/Portfile
@@ -35,7 +35,7 @@ configure.args-append \
 # then used for building, but not at runtime.
 
 set pythons2_suffixes {27}
-set pythons3_suffixes {36 37 38 39}
+set pythons3_suffixes {310 311 312 313 314}
 
 set pythons_ports {}
 foreach s ${pythons2_suffixes} {
@@ -68,12 +68,12 @@ foreach s ${pythons2_suffixes} {
     depends_lib-append \
         port:${p}
     depends_build-append \
-        port:swig-python
+        port:swig-python \
+        port:py${s}-setuptools
     # specify the Python version to use
-    configure.args-delete \
-        -DENABLE_PYTHON=OFF
+    configure.args-replace \
+        -DENABLE_PYTHON=OFF -DENABLE_PYTHON=ON
     configure.args-append \
-        -DENABLE_PYTHON=ON \
         -DPYTHON_EXECUTABLE=${frameworks_dir}/Python.framework/Versions/${v}/bin/python${v} \
         -DPYTHON_CONFIG_EXECUTABLE=${frameworks_dir}/Python.framework/Versions/${v}/bin/python${v}-config \
         -DPYTHON_INSTALL_DIR=${frameworks_dir}/Python.framework/Versions/${v}/lib/python${v}/site-packages
@@ -90,12 +90,12 @@ foreach s ${pythons3_suffixes} {
     depends_lib-append \
         port:${p}
     depends_build-append \
-        port:swig-python
+        port:swig-python \
+        port:py${s}-setuptools
     # specify the Python version to use
-    configure.args-delete \
-        -DENABLE_PYTHON3=OFF
+    configure.args-replace \
+        -DENABLE_PYTHON3=OFF -DENABLE_PYTHON3=ON
     configure.args-append \
-        -DENABLE_PYTHON3=ON \
         -DPYTHON3_EXECUTABLE=${frameworks_dir}/Python.framework/Versions/${v}/bin/python${v} \
         -DPYTHON3_CONFIG_EXECUTABLE=${frameworks_dir}/Python.framework/Versions/${v}/bin/python${v}-config \
         -DPYTHON3_INSTALL_DIR=${frameworks_dir}/Python.framework/Versions/${v}/lib/python${v}/site-packages