diff --git a/science/stimfit/Portfile b/science/stimfit/Portfile
index 525b396040f..47cf4f1eead 100644
--- a/science/stimfit/Portfile
+++ b/science/stimfit/Portfile
@@ -2,12 +2,13 @@
 
 PortSystem          1.0
 PortGroup           wxWidgets 1.0
+PortGroup           cmake 1.1
 
 name                stimfit
-version             0.16.11
-checksums           rmd160  c0711ab55543f5c292d0869b4ad2878e6d199c4e \
-                    sha256  d8a543e116a281fb45fdd292518ed1e3bc8f466332db780a1641089ee5a568d9 \
-                    size    1917433
+version             0.17.1
+checksums           rmd160  c07ad51c7dddb533aaa1edb544386c2c8875b4b5 \
+                    sha256  c6a5761644d9fb6504a097b9232197a0e65cc6f19afb9162c2e20a39e2efcf84 \
+                    size    20174648
 
 categories          science
 license             GPL-2
@@ -16,10 +17,12 @@ description         Electrophysiology analysis suite
 long_description    A program for viewing and analyzing electrophysiological data
 homepage            http://www.stimfit.org
 master_sites        ${homepage}
+worksrcdir          Stimfit-${version}-Source
 
 wxWidgets.use       wxWidgets-3.2
 
-depends_build       port:gawk
+depends_build-append \
+                    port:gawk
 
 depends_lib         port:fftw-3 \
                     port:hdf5 \
@@ -28,11 +31,16 @@ depends_lib         port:fftw-3 \
 compiler.cxx_standard \
                     2017
 
-configure.args      --disable-dependency-tracking \
-                    --disable-silent-rules \
-                    --disable-python \
-                    --with-biosiglite \
-                    --with-wx-config=${wxWidgets.wxconfig}
+configure.args      -DCMAKE_INSTALL_PREFIX=${applications_dir} \
+                    -DSTF_ENABLE_PYTHON=OFF \
+                    -DSTF_WITH_BIOSIG=ON \
+                    -DSTF_BIOSIG_PROVIDER=SUBMODULE \
+                    -DSTF_BUILD_MODULE=OFF \
+                    -DSTF_BUILD_TESTS=OFF \
+                    -DSTF_MACOS_APP_BUNDLE=ON \
+                    -DwxWidgets_CONFIG_EXECUTABLE=${wxWidgets.wxconfig}
+
+configure.pre_args  -S ${worksrcpath} -B ${workpath}/build
 
 set python_branches {3.10 3.11 3.12 3.13 3.14}
 
@@ -83,16 +91,16 @@ foreach python_branch ${python_branches} {
             port:py${python_version}-numpy \
             port:py${python_version}-matplotlib
 
-        configure.python \
-            ${prefix}/bin/python${python_branch}
+        configure.args-replace \
+            -DSTF_ENABLE_PYTHON=OFF \
+            -DSTF_ENABLE_PYTHON=ON
 
         configure.args-replace \
-            --disable-python \
-            --enable-python
+            -DwxWidgets_CONFIG_EXECUTABLE=${wxWidgets.wxconfig} \
+            -DwxWidgets_CONFIG_EXECUTABLE=${frameworks_dir}/Python.framework/Versions/${python_branch}/bin/wx-config
 
-        configure.args-replace \
-            --with-wx-config=${wxWidgets.wxconfig} \
-            --with-wx-config=${frameworks_dir}/Python.framework/Versions/${python_branch}/bin/wx-config
+        configure.args-append \
+            -DPython3_EXECUTABLE=${prefix}/bin/python${python_branch}
     }
 }
 
@@ -101,14 +109,12 @@ variant atlas description {Use MacPorts ATLAS libraries} {
         port:atlas
 
     configure.args-append \
-        --with-lapack-lib=${prefix}/lib/libatlas.a
+        -DBLA_VENDOR=ATLAS
 }
 
 configure.ldflags-append \
                     -headerpad_max_install_names
 
-destroot.destdir    DESTDIR=${destroot}${applications_dir}
-
 post-destroot {
     set docdir ${destroot}${prefix}/share/doc/${name}
     xinstall -d ${docdir}