diff --git a/gnome/gtkmm4/Portfile b/gnome/gtkmm4/Portfile
index 1636b787e0f..fc43e100553 100644
--- a/gnome/gtkmm4/Portfile
+++ b/gnome/gtkmm4/Portfile
@@ -6,7 +6,7 @@ PortGroup           meson 1.0
 
 name                gtkmm4
 set gname           gtkmm
-version             4.14.0
+version             4.22.0
 revision            0
 
 categories          gnome devel
@@ -24,9 +24,9 @@ dist_subdir         ${gname}
 distname            ${gname}-${version}
 use_xz              yes
 
-checksums           rmd160  88254ec90b23de9db6bb4440d2367b6d4379fd75 \
-                    sha256  9350a0444b744ca3dc69586ebd1b6707520922b6d9f4f232103ce603a271ecda \
-                    size    16713784
+checksums           rmd160  4976f6e2105b6d7eb16ae58fa2d576f2f645bc2b \
+                    sha256  2e8a21b4b0725f620e33aaee0cd343ed121b533275b632896619b1c89e96de67 \
+                    size    17841520
 
 # Disable unexpected download of subprojects
 meson.wrap_mode     nodownload
@@ -59,26 +59,15 @@ depends_skip_archcheck-append \
 
 compiler.cxx_standard 2017
 
-configure.perl      /usr/bin/perl
 configure.python    ${prefix}/bin/python${py_ver}
-configure.env-append \
-                    PERL_PATH=${configure.perl}
+
+meson.native.binaries   python=${configure.python}
 
 configure.args-append \
                     -Dbuild-demos=false \
                     -Dbuild-documentation=false \
                     -Dbuild-tests=false
 
-patchfiles-append \
-                    patch-meson-build-python-path.diff \
-                    patch-aboutdialog.diff
-
-post-patch {
-    reinplace -W ${worksrcpath} \
-        "s|@@PYTHON@@|${configure.python}|" \
-        meson.build
-}
-
 variant x11 conflicts quartz {
     require_active_variants path:lib/pkgconfig/cairomm.pc:cairomm x11
     require_active_variants path:lib/pkgconfig/gtk4.pc:gtk4 x11
diff --git a/gnome/gtkmm4/files/patch-aboutdialog.diff b/gnome/gtkmm4/files/patch-aboutdialog.diff
deleted file mode 100644
index 1f45873e878..00000000000
--- a/gnome/gtkmm4/files/patch-aboutdialog.diff
+++ /dev/null
@@ -1,11 +0,0 @@
-https://gitlab.gnome.org/GNOME/gtkmm/-/issues/157
---- untracked/gtk/gtkmm/aboutdialog.h.orig	2024-03-17 14:38:29
-+++ untracked/gtk/gtkmm/aboutdialog.h	2024-06-02 00:27:40
-@@ -124,6 +124,7 @@
-   GPL_3_0,
-   LGPL_2_1,
-   LGPL_3_0,
-+#undef BSD
-   BSD,
-   MIT_X11,
-   ARTISTIC,
diff --git a/gnome/gtkmm4/files/patch-meson-build-python-path.diff b/gnome/gtkmm4/files/patch-meson-build-python-path.diff
deleted file mode 100644
index b0341a0f86f..00000000000
--- a/gnome/gtkmm4/files/patch-meson-build-python-path.diff
+++ /dev/null
@@ -1,11 +0,0 @@
---- meson.build.orig	2023-08-08 07:40:41.000000000 -0400
-+++ meson.build	2023-08-10 07:31:27.000000000 -0400
-@@ -47,7 +47,7 @@
- cpp_compiler = meson.get_compiler('cpp')
- is_msvc = cpp_compiler.get_id() == 'msvc'
- is_host_windows = host_machine.system() == 'windows'
--python3 = find_program('python3', version: '>=3.5')
-+python3 = find_program('@@PYTHON@@', version: '>=3.5')
- 
- # Do we build from a git repository?
- # Suppose we do if and only if the meson.build file is tracked by git.