diff --git a/src/xenia/kernel/xam/xam_info.cc b/src/xenia/kernel/xam/xam_info.cc
index 1d860aeb2..7b9ca810f 100644
--- a/src/xenia/kernel/xam/xam_info.cc
+++ b/src/xenia/kernel/xam/xam_info.cc
@@ -407,9 +407,10 @@ void XamLoaderLaunchTitle_entry(lpstring_t raw_name_ptr, dword_t flags) {
       XELOGI("XamLoaderLaunchTitle: original host_path={}, launch_path={}",
              loader_data.host_path, launch_path);
 
-      // Remove common guest path prefixes
+      // Remove common guest path prefixes (case-insensitive since Xbox
+      // paths are case-insensitive, games may pass e.g. "GAME:\")
       auto remove_prefix = [&launch_path](std::string_view prefix) {
-        if (launch_path.compare(0, prefix.length(), prefix) == 0) {
+        if (xe::utf8::starts_with_case(launch_path, prefix)) {
           launch_path = launch_path.substr(prefix.length());
         }
       };
diff --git a/src/xenia/vfs/virtual_file_system.cc b/src/xenia/vfs/virtual_file_system.cc
index 8e7454857..d3050ec45 100644
--- a/src/xenia/vfs/virtual_file_system.cc
+++ b/src/xenia/vfs/virtual_file_system.cc
@@ -134,7 +134,7 @@ Entry* VirtualFileSystem::ResolvePath(const std::string_view path) {
   // Find the device.
   auto it =
       std::find_if(devices_.cbegin(), devices_.cend(), [&](const auto& d) {
-        return xe::utf8::starts_with(normalized_path, d->mount_path());
+        return xe::utf8::starts_with_case(normalized_path, d->mount_path());
       });
   if (it == devices_.cend()) {
     // Supress logging the error for ShaderDumpxe:\CompareBackEnds as this is