diff --git a/Source/Core/Core/AchievementManager.cpp b/Source/Core/Core/AchievementManager.cpp
index 49457e431a..ac9d041b62 100644
--- a/Source/Core/Core/AchievementManager.cpp
+++ b/Source/Core/Core/AchievementManager.cpp
@@ -14,6 +14,8 @@
 #include "Core/Core.h"
 #include "DiscIO/Volume.h"
 
+static constexpr bool hardcore_mode_enabled = false;
+
 AchievementManager* AchievementManager::GetInstance()
 {
   static AchievementManager s_instance;
@@ -131,15 +133,86 @@ void AchievementManager::LoadGameByFilenameAsync(const std::string& iso_path,
 
     const auto fetch_game_data_response = FetchGameData();
     m_is_game_loaded = fetch_game_data_response == ResponseType::SUCCESS;
+
+    // Claim the lock, then queue the fetch unlock data calls, then initialize the unlock map in
+    // ActivateDeactiveAchievements. This allows the calls to process while initializing the
+    // unlock map but then forces them to wait until it's initialized before making modifications to
+    // it.
+    {
+      std::lock_guard lg{m_lock};
+      LoadUnlockData([](ResponseType r_type) {});
+      ActivateDeactivateAchievements();
+    }
+    ActivateDeactivateLeaderboards();
+    ActivateDeactivateRichPresence();
+
     callback(fetch_game_data_response);
   });
 }
 
+void AchievementManager::LoadUnlockData(const ResponseCallback& callback)
+{
+  m_queue.EmplaceItem([this, callback] {
+    const auto hardcore_unlock_response = FetchUnlockData(true);
+    if (hardcore_unlock_response != ResponseType::SUCCESS)
+    {
+      callback(hardcore_unlock_response);
+      return;
+    }
+
+    callback(FetchUnlockData(false));
+  });
+}
+
+void AchievementManager::ActivateDeactivateAchievements()
+{
+  bool enabled = Config::Get(Config::RA_ACHIEVEMENTS_ENABLED);
+  bool unofficial = Config::Get(Config::RA_UNOFFICIAL_ENABLED);
+  bool encore = Config::Get(Config::RA_ENCORE_ENABLED);
+  for (u32 ix = 0; ix < m_game_data.num_achievements; ix++)
+  {
+    auto iter =
+        m_unlock_map.insert({m_game_data.achievements[ix].id, UnlockStatus{.game_data_index = ix}});
+    ActivateDeactivateAchievement(iter.first->first, enabled, unofficial, encore);
+  }
+}
+
+void AchievementManager::ActivateDeactivateLeaderboards()
+{
+  bool leaderboards_enabled = Config::Get(Config::RA_LEADERBOARDS_ENABLED);
+  for (u32 ix = 0; ix < m_game_data.num_leaderboards; ix++)
+  {
+    auto leaderboard = m_game_data.leaderboards[ix];
+    if (m_is_game_loaded && leaderboards_enabled && hardcore_mode_enabled)
+    {
+      rc_runtime_activate_lboard(&m_runtime, leaderboard.id, leaderboard.definition, nullptr, 0);
+    }
+    else
+    {
+      rc_runtime_deactivate_lboard(&m_runtime, m_game_data.leaderboards[ix].id);
+    }
+  }
+}
+
+void AchievementManager::ActivateDeactivateRichPresence()
+{
+  rc_runtime_activate_richpresence(
+      &m_runtime,
+      (m_is_game_loaded && Config::Get(Config::RA_RICH_PRESENCE_ENABLED)) ?
+          m_game_data.rich_presence_script :
+          "",
+      nullptr, 0);
+}
+
 void AchievementManager::CloseGame()
 {
   m_is_game_loaded = false;
   m_game_id = 0;
   m_queue.Cancel();
+  m_unlock_map.clear();
+  ActivateDeactivateAchievements();
+  ActivateDeactivateLeaderboards();
+  ActivateDeactivateRichPresence();
 }
 
 void AchievementManager::Logout()
@@ -214,6 +287,85 @@ AchievementManager::ResponseType AchievementManager::FetchGameData()
       rc_api_process_fetch_game_data_response);
 }
 
+AchievementManager::ResponseType AchievementManager::FetchUnlockData(bool hardcore)
+{
+  rc_api_fetch_user_unlocks_response_t unlock_data{};
+  std::string username = Config::Get(Config::RA_USERNAME);
+  std::string api_token = Config::Get(Config::RA_API_TOKEN);
+  rc_api_fetch_user_unlocks_request_t fetch_unlocks_request = {.username = username.c_str(),
+                                                               .api_token = api_token.c_str(),
+                                                               .game_id = m_game_id,
+                                                               .hardcore = hardcore};
+  ResponseType r_type =
+      Request<rc_api_fetch_user_unlocks_request_t, rc_api_fetch_user_unlocks_response_t>(
+          fetch_unlocks_request, &unlock_data, rc_api_init_fetch_user_unlocks_request,
+          rc_api_process_fetch_user_unlocks_response);
+  if (r_type == ResponseType::SUCCESS)
+  {
+    std::lock_guard lg{m_lock};
+    bool enabled = Config::Get(Config::RA_ACHIEVEMENTS_ENABLED);
+    bool unofficial = Config::Get(Config::RA_UNOFFICIAL_ENABLED);
+    bool encore = Config::Get(Config::RA_ENCORE_ENABLED);
+    for (AchievementId ix = 0; ix < unlock_data.num_achievement_ids; ix++)
+    {
+      auto it = m_unlock_map.find(unlock_data.achievement_ids[ix]);
+      if (it == m_unlock_map.end())
+        continue;
+      it->second.remote_unlock_status =
+          hardcore ? UnlockStatus::UnlockType::HARDCORE : UnlockStatus::UnlockType::SOFTCORE;
+      ActivateDeactivateAchievement(unlock_data.achievement_ids[ix], enabled, unofficial, encore);
+    }
+  }
+  rc_api_destroy_fetch_user_unlocks_response(&unlock_data);
+  return r_type;
+}
+
+void AchievementManager::ActivateDeactivateAchievement(AchievementId id, bool enabled,
+                                                       bool unofficial, bool encore)
+{
+  auto it = m_unlock_map.find(id);
+  if (it == m_unlock_map.end())
+    return;
+  const UnlockStatus& status = it->second;
+  u32 index = status.game_data_index;
+  bool active = (rc_runtime_get_achievement(&m_runtime, id) != nullptr);
+
+  // Deactivate achievements if game is not loaded
+  bool activate = m_is_game_loaded;
+  // Activate achievements only if achievements are enabled
+  if (activate && !enabled)
+    activate = false;
+  // Deactivate if achievement is unofficial, unless unofficial achievements are enabled
+  if (activate && !unofficial &&
+      m_game_data.achievements[index].category == RC_ACHIEVEMENT_CATEGORY_UNOFFICIAL)
+  {
+    activate = false;
+  }
+  // If encore mode is on, activate/deactivate regardless of current unlock status
+  if (activate && !encore)
+  {
+    // Encore is off, achievement has been unlocked in this session, deactivate
+    activate = (status.session_unlock_count == 0);
+    // Encore is off, achievement has been hardcore unlocked on site, deactivate
+    if (activate && status.remote_unlock_status == UnlockStatus::UnlockType::HARDCORE)
+      activate = false;
+    // Encore is off, hardcore is off, achievement has been softcore unlocked on site, deactivate
+    if (activate && !hardcore_mode_enabled &&
+        status.remote_unlock_status == UnlockStatus::UnlockType::SOFTCORE)
+    {
+      activate = false;
+    }
+  }
+
+  if (!active && activate)
+  {
+    rc_runtime_activate_achievement(&m_runtime, id, m_game_data.achievements[index].definition,
+                                    nullptr, 0);
+  }
+  if (active && !activate)
+    rc_runtime_deactivate_achievement(&m_runtime, id);
+}
+
 // Every RetroAchievements API call, with only a partial exception for fetch_image, follows
 // the same design pattern (here, X is the name of the call):
 //   Create a specific rc_api_X_request_t struct and populate with the necessary values
diff --git a/Source/Core/Core/AchievementManager.h b/Source/Core/Core/AchievementManager.h
index ecbf236d60..b759386721 100644
--- a/Source/Core/Core/AchievementManager.h
+++ b/Source/Core/Core/AchievementManager.h
@@ -8,6 +8,7 @@
 #include <mutex>
 #include <string>
 #include <thread>
+#include <unordered_map>
 
 #include <rcheevos/include/rc_api_runtime.h>
 #include <rcheevos/include/rc_api_user.h>
@@ -16,6 +17,8 @@
 #include "Common/Event.h"
 #include "Common/WorkQueueThread.h"
 
+using AchievementId = u32;
+
 class AchievementManager
 {
 public:
@@ -36,6 +39,11 @@ public:
   bool IsLoggedIn() const;
   void LoadGameByFilenameAsync(const std::string& iso_path, const ResponseCallback& callback);
 
+  void LoadUnlockData(const ResponseCallback& callback);
+  void ActivateDeactivateAchievements();
+  void ActivateDeactivateLeaderboards();
+  void ActivateDeactivateRichPresence();
+
   void CloseGame();
   void Logout();
   void Shutdown();
@@ -49,6 +57,9 @@ private:
   ResponseType ResolveHash(std::array<char, HASH_LENGTH> game_hash);
   ResponseType StartRASession();
   ResponseType FetchGameData();
+  ResponseType FetchUnlockData(bool hardcore);
+
+  void ActivateDeactivateAchievement(AchievementId id, bool enabled, bool unofficial, bool encore);
 
   template <typename RcRequest, typename RcResponse>
   ResponseType Request(RcRequest rc_request, RcResponse* rc_response,
@@ -61,7 +72,21 @@ private:
   rc_api_fetch_game_data_response_t m_game_data{};
   bool m_is_game_loaded = false;
 
+  struct UnlockStatus
+  {
+    AchievementId game_data_index = 0;
+    enum class UnlockType
+    {
+      LOCKED,
+      SOFTCORE,
+      HARDCORE
+    } remote_unlock_status = UnlockType::LOCKED;
+    int session_unlock_count = 0;
+  };
+  std::unordered_map<AchievementId, UnlockStatus> m_unlock_map;
+
   Common::WorkQueueThread<std::function<void()>> m_queue;
+  std::recursive_mutex m_lock;
 };  // class AchievementManager
 
 #endif  // USE_RETRO_ACHIEVEMENTS
diff --git a/Source/Core/Core/Config/AchievementSettings.cpp b/Source/Core/Core/Config/AchievementSettings.cpp
index f7ec642881..3499fcc791 100644
--- a/Source/Core/Core/Config/AchievementSettings.cpp
+++ b/Source/Core/Core/Config/AchievementSettings.cpp
@@ -13,4 +13,13 @@ namespace Config
 const Info<bool> RA_ENABLED{{System::Achievements, "Achievements", "Enabled"}, false};
 const Info<std::string> RA_USERNAME{{System::Achievements, "Achievements", "Username"}, ""};
 const Info<std::string> RA_API_TOKEN{{System::Achievements, "Achievements", "ApiToken"}, ""};
+const Info<bool> RA_ACHIEVEMENTS_ENABLED{
+    {System::Achievements, "Achievements", "AchievementsEnabled"}, false};
+const Info<bool> RA_LEADERBOARDS_ENABLED{
+    {System::Achievements, "Achievements", "LeaderboardsEnabled"}, false};
+const Info<bool> RA_RICH_PRESENCE_ENABLED{
+    {System::Achievements, "Achievements", "RichPresenceEnabled"}, false};
+const Info<bool> RA_UNOFFICIAL_ENABLED{{System::Achievements, "Achievements", "UnofficialEnabled"},
+                                       false};
+const Info<bool> RA_ENCORE_ENABLED{{System::Achievements, "Achievements", "EncoreEnabled"}, false};
 }  // namespace Config
diff --git a/Source/Core/Core/Config/AchievementSettings.h b/Source/Core/Core/Config/AchievementSettings.h
index 8f26769d7f..33318f7400 100644
--- a/Source/Core/Core/Config/AchievementSettings.h
+++ b/Source/Core/Core/Config/AchievementSettings.h
@@ -11,4 +11,9 @@ namespace Config
 extern const Info<bool> RA_ENABLED;
 extern const Info<std::string> RA_USERNAME;
 extern const Info<std::string> RA_API_TOKEN;
+extern const Info<bool> RA_ACHIEVEMENTS_ENABLED;
+extern const Info<bool> RA_LEADERBOARDS_ENABLED;
+extern const Info<bool> RA_RICH_PRESENCE_ENABLED;
+extern const Info<bool> RA_UNOFFICIAL_ENABLED;
+extern const Info<bool> RA_ENCORE_ENABLED;
 }  // namespace Config